[HTML][HTML] 3D tumor angiogenesis models: recent advances and challenges

SM Bhat, VA Badiger, S Vasishta, J Chakraborty… - Journal of Cancer …, 2021 - Springer
… the qualitative and quantitative expression of pro and anti-angiogenic molecules. As …
on tumor endothelial cell biology. Further, 3-dimensional (3D) cultures were also developed

[HTML][HTML] In vitro 3D Systems to Model Tumor Angiogenesis and Interactions With Stromal Cells

N Brassard-Jollive, C Monnot, L Muller… - Frontiers in cell and …, 2020 - frontiersin.org
… to anti-cancer therapies such as anti-angiogenic, radio-, and … the impact of shear stress and
interstitial flow and growth factor … Endothelial cells are seeded on Cytodex beads (blue) and …

Establishment of a 3D model of tumor-driven angiogenesis to study the effects of anti-angiogenic drugs on pericyte recruitment

Y Qiu, N Wang, T Guo, S Liu, X Tang, Z Zhong… - Biomaterials …, 2021 - pubs.rsc.org
… In this study, we developed a microcarrier-based 3D model of tumor-driven angiogenesis
composed of endothelial cells, … for investigating the interactions between endothelial cells and …

[HTML][HTML] New artery of knowledge: 3D models of angiogenesis

E Zucchelli, QA Majid, G Foldes - Vascular Biology, 2019 - vb.bioscientifica.com
development, via the differentiation of endothelial cell … , anti-angiogenic therapy targeting
angiogenic growth factors … on endothelial cells and the interactions between endothelial

Anti-angiogenic agents—overcoming tumour endothelial cell anergy and improving immunotherapy outcomes

ZR Huinen, EJM Huijbers, JR van Beijnum… - Nature Reviews …, 2021 - nature.com
… how the angiogenesis-induced endothelial immune cell barrier … We developed in vivo
models to demonstrate that the … Upon interaction with tumour cells, T cells lose their ability to …

[HTML][HTML] Modeling the efficacy of different anti-angiogenic drugs on treatment of solid tumors using 3D computational modeling and machine learning

M Mousavi, MD Manshadi, M Soltani… - … in biology and medicine, 2022 - Elsevier
… of tumor cell proliferation and endothelial cell angiogenesis … on the three-dimensional
simulation of tumor growth, with … explicit knowledge of underlying interactions. While mathematical …

Microfluidic modelling of the tumor microenvironment for anti-cancer drug development

M Shang, RH Soon, CT Lim, BL Khoo, J Han - Lab on a Chip, 2019 - pubs.rsc.org
… Therefore, many 3D tumor models which are more … and gradually grown into a circular
endothelial cell layer. In this … an important role in tumor angiogenesis. Its interplay with malignant …

[HTML][HTML] … to evaluate the antiangiogenic potential of melatonin to neutralize the angiogenic effects of VEGF and breast cancer cells: CAM assay and 3D endothelial cell …

A Laborda-Illanes, L Sánchez-Alcoholado… - Biomedicine & …, 2023 - Elsevier
study was to develop rapid, economic, high capacity and easy handling angiogenesis assays
to test the antiangiogenic effectscancer cells interacts with VEGF receptors in endothelial

[HTML][HTML] Patient-specific organotypic blood vessels as an in vitro model for anti-angiogenic drug response testing in renal cell carcinoma

JA Jiménez-Torres, M Virumbrales-Muñoz, KE Sung… - …, 2019 - thelancet.com
… lumen model with primary patient-specific endothelial cells, … supply of nutrients and driving
tumor growth and metastasis. … Although the inhibition of angiogenesis has been found to be …

The anti-angiogenic effect of atorvastatin loaded exosomes on glioblastoma tumor cells: An in vitro 3D culture model

E Valipour, FE Ranjbar, M Mousavi, J Ai… - Microvascular …, 2022 - Elsevier
… exposed to hypoxia and nutrient deficiency, leading to rapid tumor growth and metastasis. …
-tumor effects on glioblastoma cells through directly inhibiting endothelial cell angiogenesis